Genetically Engineered Models and Services

At TME Scientific, we provide comprehensive solutions for the design, creation, validation, and colony management of genetically engineered animal models. With expertise spanning custom transgenesis, gene editing, and complex model development, we support your research from early discovery through preclinical validation—ensuring your models are reliable, reproducible, and ready for translational impact.

Services :

Rat and Mouse Model Creation

We offer a full suite of services to support the generation, preservation, and management of custom mouse and rat models, helping you accelerate your research with precision and efficiency.

Genetic Testing Services

Our in-house genotyping and assay development services provide rapid and accurate validation of genetic constructs. We offer zygosity testing, background strain characterization, and speed congenics to ensure your models meet experimental requirements.

Cryopreservation

Preserve valuable lines for long-term use. We provide secure cryostorage for live colonies or archived strains.

Animal Quarantine

Protect your vivarium with our quarantine services. We perform comprehensive health screenings and containment protocols to safeguard against pathogen transfer when receiving animals from external sources.

Proof-of-Concept Non-GLP Studies

TME Scientific offers flexible, rapid-turnaround non-GLP studies to support early-stage discovery and proof-of-concept validation. These studies are ideal for evaluating efficacy, optimizing dosing strategies, and informing go/no-go decisions before committing to formal GLP or IND-enabling programs.

Project Management

Our dedicated project management team ensures seamless execution of every study—from design and scheduling to data delivery. With transparent communication, milestone tracking, and scientific oversight, we keep your timelines on track and your objectives clearly aligned with study outcomes.

FAQs :

  • We use advanced gene-editing technologies such as CRISPR/Cas9 to create precise modifications, including knockouts, knock-ins, and conditional alleles. Our services cover the full pipeline—from vector design to founder screening and colony expansion.

  • Our colony management services ensure genetic consistency, health monitoring, and breeding optimization, saving you time and facility resources. We also provide cryopreservation, rederivation, and secure long-term storage solutions.

  • Yes. Using laser-assisted IVF and colony expansion technologies, we can scale production from a few breeding pairs to hundreds of animals, supporting even the most demanding preclinical timelines.

  • Contact our team via the inquiry form or email (info@tmescientific.com). We’ll schedule a consultation to discuss your study goals, model specifications, and service needs. From there, we provide a custom proposal and project timeline.