Human IL-5
Interleukin-5 (IL-5) is a key cytokine that regulates eosinophil development, activation, and survival. Secreted primarily by type 2 helper T (Th2) cells, mast cells, and eosinophils, IL-5 binds to its receptor (IL-5R) on target cells, triggering signaling pathways that drive eosinophil differentiation, proliferation, and adhesion to endothelial cells. This enhances eosinophil recruitment and degranulation, contributing to allergic inflammation and immune defense against parasitic infections. In conditions such as asthma, IL-5 promotes eosinophil accumulation in the airways, leading to bronchial inflammation.
Recombinant human IL-5 can be used in vitro to study eosinophil biology, cytokine signaling, and immune regulation. It serves as a valuable tool for investigating signal transduction, gene expression, and cellular responses in hematopoietic progenitor cells and mature eosinophils. Additionally, it plays a crucial role in drug discovery, aiding in the development of targeted therapies for eosinophil-associated diseases and allergic disorders.
| Cat. No. | RC0005 |
|---|---|
| Purity | >95% in SDS-PAGE followed by coomassie staining |
| Endotoxin Level | <0.01 EU/µg (LAL Assay) |
| Source | Purified from the culture supernatant of HEK 293 cells genetically engineered to express human IL-5 protein with a C-terminal His tag. |
| Accession # | NP_000870 |
| Applications/Intended Use | Research Use Only: This product is intended for laboratory research use only. It is not intended for any animal or human therapeutic use, any human or animal consumption, or any diagnostic use. |
| Molecular Mass | Predicted mass (12.7 kDa), appears 20 - 25 kDa due to glycosylation |
| Formulation | Lyophilized from a 0.1 μm filtered solution in PBS with Trehalose |
| Reconstitution | Dissolve in sterile PBS to 0.1-0.5 mg/mL or user preferred stock concentration. |
| Shipping or Handling Information | Shipped at ambient temperature |
| CoA | Batch-specific test results will be provided with the product |
| Stability | Lyophilized: Stable for 12 months at -80°C; Reconstituted: Stable for 2 weeks at 4°C, or 3-6 months at -20°C |
| Disclaimer | All of TME Scientific cell biology products are for research use ONLY and NOT for therapeutic/diagnostic applications. TME Scientific is not liable for any repercussions arising from the use of its cell biology product(s) in therapeutic/diagnostic or any other non-RUO application(s). |
