In Vitro Toxicology Assays

In preclinical studies, in vitro toxicology assays are essential tools to evaluate the safety, mechanism of toxicity, and risk potential of drugs, biologics, and chemicals before entering animal testing or clinical trials. These assays reduce reliance on animal models, help prioritize drug candidates, and are often aligned with regulatory expectations from agencies like the FDA and EMA.

Drug-induced toxicities - particularly hepatotoxicity and cardiotoxicity - are among the leading reasons for drug withdrawal from the market. Many potential drug candidates are eliminated during development due to unacceptable toxicity levels. As a result, accurately predicting toxic effects early in the development process is critical for improving the chances of success. Early-stage toxicity testing helps reduce the risk of failure in preclinical or clinical trials, saving both time and cost. Thus, human-relevant cell-based models are being introduced in drug discovery to address this need. Compared to in vivo studies, in vitro toxicity assays are especially valuable at this stage due to their faster turnaround times and lower cost.

TME Scientific offers a full range of in vitro toxicology assays with primary cells, cancer cell lines and organoids. These assays can be performed either as standalone services or part of a fully integrated preclinical development package.