Human GM-CSF
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a key cytokine that regulates hematopoiesis, immune activation, and inflammation. Produced by T cells, macrophages, and endothelial cells, it stimulates granulocyte and macrophage differentiation and enhances their function. By binding to its receptor (GM-CSFR), GM-CSF activates JAK/STAT, PI3K/Akt, and MAPK signaling, promoting immune defense, tissue repair, and inflammation. Dysregulated GM-CSF is linked to autoimmune diseases and cancer.
Recombinant GM-CSF is extensively applied in vitro to study myeloid cell differentiation, cytokine production, and antigen presentation. It also supports drug discovery for immunotherapies and treatments for neutropenia, autoimmune diseases, and cancer, aiding research in immune modulation and regenerative medicine.
| Cat. No. | RC01H |
|---|---|
| Purity | >95% in SDS-PAGE followed by coomassie staining |
| Endotoxin Level | <0.01 EU/µg (LAL Assay) |
| Source | Purified from the culture supernatant of HEK 293 cells genetically engineered to express human GM-CSF protein with a C-terminal His tag. |
| Accession # | AAA52578 |
| Applications/Intended Use | Research Use Only: This product is intended for laboratory research use only. It is not intended for any animal or human therapeutic use, any human or animal consumption, or any diagnostic use. |
| Molecular Mass | Predicted mass (14.2 kDa), appears ~25 kDa due to glycosylation |
| Formulation | Lyophilized from a 0.1 μm filtered solution in PBS with Trehalose |
| Reconstitution | Dissolve in sterile PBS to 0.1-0.5 mg/mL or user preferred stock concentration. |
| Shipping or Handling Information | Shipped at ambient temperature |
| CoA | Batch-specific test results will be provided with the product |
| Stability | Lyophilized: Stable for 12 months at -80°C; Reconstituted: Stable for 2 weeks at 4°C, or 3-6 months at -20°C |
| Disclaimer | All of TME Scientific cell biology products are for research use ONLY and NOT for therapeutic/diagnostic applications. TME Scientific is not liable for any repercussions arising from the use of its cell biology product(s) in therapeutic/diagnostic or any other non-RUO application(s). |
