Human IL-17A
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Interleukin-17A (IL-17A) is a pro-inflammatory cytokine mainly produced by Th17 cells. It plays a vital role in immune defense, driving neutrophil recruitment and strengthening epithelial barriers against bacterial and fungal infections. However, excessive IL-17A activity is linked to autoimmune diseases such as psoriasis, rheumatoid arthritis, and multiple sclerosis, contributing to chronic inflammation.
Recombinant IL-17 is frequently used to study immune responses, inflammation, and autoimmune diseases, as well as to develop targeted therapies for conditions like psoriasis, arthritis, and cancer.
| Cat. No. | RC0017A |
|---|---|
| Purity | >95% in SDS-PAGE followed by coomassie staining |
| Endotoxin Level | <0.01 EU/µg (LAL Assay) |
| Source | Purified from the culture supernatant of HEK 293 cells genetically engineered to express human IL-17A protein with a C-terminal His tag. |
| Accession # | NP_002181 |
| Applications/Intended Use | Research Use Only: This product is intended for laboratory research use only. It is not intended for any animal or human therapeutic use, any human or animal consumption, or any diagnostic use. |
| Molecular Mass | Predicted mass (14.6 kDa), appears 17 - 43 kDa due to glycosylation |
| Formulation | Lyophilized from a 0.1 μm filtered solution in PBS with Trehalose |
| Reconstitution | Dissolve in sterile PBS to 0.1-0.5 mg/mL or user preferred stock concentration. |
| Shipping or Handling Information | Shipped at ambient temperature |
| CoA | Batch-specific test results will be provided with the product |
| Stability | Lyophilized: Stable for 12 months at -80°C; Reconstituted: Stable for 2 weeks at 4°C, or 3-6 months at -20°C |
| Disclaimer | All of TME Scientific cell biology products are for research use ONLY and NOT for therapeutic/diagnostic applications. TME Scientific is not liable for any repercussions arising from the use of its cell biology product(s) in therapeutic/diagnostic or any other non-RUO application(s). |
