Partner Services

At TME Scientific, we support more than model generation. Through our network of GLP- and AAALAC-certified partners, we provide access to a full range of in vivo and in vitro research services to support early-stage drug discovery and preclinical development. These partnerships allow us to offer integrated, high-quality solutions that help you move faster and more confidently from idea to IND.

Whether you need to evaluate pharmacokinetics, assess safety, or demonstrate in vivo efficacy, our extended services are built to accelerate your timeline and reduce development risk.

Safety Evaluation

Safety evaluation is a critical part of new drug development and essential for regulatory approval. With our network of trusted partners, we offer a one-stop shop for preclinical R&D services—including pharmacology, pharmacokinetics, and comprehensive safety studies—for both drugs and medical devices. Our partner services follow standardized protocols and generate high-quality data that meet NMPA, OECD, and FDA requirements.

Key Services

  • Toxicity Studies: Single dose toxicity (rodents & non-rodents) and repeated dose toxicity (rodents & non-rodents)

  • Reproductive Toxicity: Fertility and Early Embryonic Development (FEED), Embryo-Fetal Development (EFD), Pre- and Postnatal Development (PPND), fetal survival rate, sperm survival rate, and hormone test.

  • Genotoxicity: ames test, micronucleus test, chromosomal aberration test, and mutagenicity

  • Carcinogenicity: short-term, long-term, and tumorigenicity/oncogenicity tests

  • Local Toxicity: hemolysis (in vivo, in vitro), anaphylaxis (ASA, PCA, ACA, GPMT, BT, etc.), and irritation tests (vessels, muscle, skin, mucosa, etc.)

  • Immunogenicity & Immunotoxicity: quantification (ELISA, MSD), conventional endpoints (blood cells, chemistry, tissues), and special endpoints (TDAR, cytokines, lymphocyte phenotyping).

  • Safety Pharmacology: circulatory (ECG, BP, temp, telemetry, hERG), respiratory (plethysmography, airway resistance), CNS (FOB, Irwin’s test), GI (ileum perfusion, propulsion, secretions), renal (urinalysis, hematology), and autonomic (heart rate variability)

  • Toxicokinetics (TK): TK/PD/TOX analysis, gender/dose / accumulation effects, TK-immunogenicity correlation, and preclinical sample bioanalysis

  • Dependency Studies: receptor binding, PK/PD, toxicology, behavioral tests (rotarod, reflexes, muscle tone), and reinforcement tests (self-administration, CPP, withdrawal)

Non-Rodent Animal Models

While mice and rats are valuable for early discovery, non-rodent species offer closer physiological and metabolic similarities to humans, making them essential for evaluating toxicology, pharmacokinetics, and drug delivery routes. Through our trusted partner network, we also provide access to a wide array of non-rodent animal models, including beagle dogs, minipigs, rabbits, and non-human primates. These models play a pivotal role in translational research by offering physiological and metabolic profiles closer to humans, particularly important for biologics, long-acting formulations, and complex delivery routes.

Routes of Administration

Standard Routes

  • Rodents (mouse, rat): gavage, IP, IV (bolus/infusion), SC, IM

  • Beagle dog: oral (gavage, capsule/tablet), IV, SC, IM

  • Non-human primates: oral, IV, SC, IM

  • Minipig: oral, IV, SC, IM, transdermal

  • Rabbit: oral, IV, SC, IM, transdermal

Special Routes

  • Intraocular (e.g., subretinal, suprachoroidal)

  • Intranasal (spray, drops)

  • Intrathecal, intracranial, intra-articular, intratumoral

  • Vaginal, rectal, intravesical

  • Inhalation (nasal/oral)

  • Surgical implantation

Sampling Techniques

  • Blood: sinus, tail vein, ear vein, heart, major arteries

  • Urine/Feces: via metabolic cage

  • Tissue Collection: paraffin/frozen sections, special processing

  • In Vivo Sampling: aqueous humor, cerebrospinal fluid, liver biopsy, bone marrow aspiration

Disease Models

Our partners support preclinical drug discovery and development with well-characterized disease models:

Oncology

  • CDX xenografts, tumor-bearing models

  • Tumor inhibition (TGI), survival analysis, histology

  • Superiority/equivalence vs. positive controls

Respiratory

  • Asthma, COPD, ILD, pulmonary fibrosis

  • Biomarker assays, protein expression, tracheal tension

Metabolic

  • Diabetes, fatty liver, liver fibrosis

  • Obesity, hyperuricemia, atherosclerosis

Neurology

  • Alzheimer’s, Parkinson’s, epilepsy, migraine

  • Pain (CCI, Chung), addiction, psychiatric disorders

  • Electrophysiology, cognition, behavioral assays

Immunology

  • Arthritis (CIA, AIA), multiple sclerosis, psoriasis

  • IgA nephropathy, respiratory inflammation

Renal & Urology

  • Drug- or surgery-induced renal injury

  • Renal failure and insufficiency

Cardiovascular

  • Myocardial infarction

  • Coronary artery disease

Other Models

  • Diabetic foot

  • Premature ovarian failure

  • Stroke (MCAO)

Why Work With Us?

  • Experienced Scientists

    A professional team with expertise in PK, pharmacology, and toxicology

  • Advanced Platforms

    Cutting-edge technology for reliable early-stage evaluations

  • Comprehensive Methods

    Multi-angle screening to fully assess candidate potential

  • Proven Success

    A strong track record of validated models and collaborative studies